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Horizon
parental test

The Horizon parental test is a screening test of up to 274 genetic condition, and provides valuable information on future parents likelihood of having a child with a genetic condition.

Most people are carriers of at least four to six genetic conditions, but most carriers are healthy because the other copy of the gene works normally. However, carrier couples are at the increased likelihood to have a child with a genetic condition, so knowing your status allows parents-to-be to make more informed reproductive decisions.

If you and your partner are both carriers of the same condition, you have a 1-in-4, or 25%, chance with each pregnancy of having a child affected with the condition. If you as a woman is a carrier of an X-linked condition, you have a 50 percent chance with each pregnancy of passing the gene mutation to your child. If the child is a boy, and he inherits the mutation, he will be affected with the condition.

Learn more about the different types of genetic conditions here.

Autosomal recessive inheritance

Both parents-to-be must be carriers of the same genetic condition to pass it on to their future child. This is known as autosomal recessive inheritance.

If both the future father and mother carry the same genetic condition, there is a 25 percent likelihood that each of their future children will be affected (regardless of gender). Meanwhile, the likelihood that the future child is just a carrier, or is completely healthy, is 75 percent.

Likelihood that baby is affected when both mother and father are carriers

Affected

Unaffected

Unaffected carrier

25%

25%

50%

X-linked inheritance

If a woman is a carrier of an X-linked condition, she has a 1-in-2, or 50%, chance with each pregnancy of passing the gene mutation to her child. If the child is a boy, and he inherits the mutation, he will be affected with the condition

Likelihood that baby is affected when only mother is a carrier

Boys

Girls

50% unaffected

50% non-carrier

50% affected

50% carrier

Duration: 30 minutes

Price, Horizon 4 genes: DKK 5,300

Horizon 4 screens for the following conditions:

  • Cystic Fibrosis
  • Fragile X Syndrome
  • Duchenne/Becker Muscular Dystrophy
  • Spinal Muscular Atrophy
Price, Horizon 27 genes: DKK 5,700

Horizon 27 screens for the following conditions:

  • Alpha-Thalassemia
  • Batten Disease, CLN3-Related
  • Beta-Hemoglobinopathies (including Sickle Cell Disease)
  • Bloom Syndrome
  • Canavan Disease
  • Citrullinemia, Type I
  • Cystic Fibrosis
  • Duchenne/Becker Muscular Dystrophy
  • Familial Dysautonomia
  • Fanconi Anemia, Group C
  • Fragile X Syndrome
  • Galactosemia
  • Gaucher Disease
  • Glycogen Storage Disease, Type 1A
  • Isovaleric Acidemia
  • Medium Chain Acyl-CoA Dehydrogenase De­ciency
  • Methylmalonic Aciduria and Homocystinuria, Type cblC
  • Mucolipidosis, Type IV
  • Mucopolysaccharidosis, Type I (Hurler Syndrome)
  • Niemann-Pick Disease, Type A/B
  • Polycystic kidney disease autosomal recessive
  • Rhizomelic chondrodysplasia punctata type 1
  • Smith-Lemli-Opitz syndrome
  • Tay-Sachs disease
  • Tyrosinemia type 1
  • Zellweger spectrum disorders PEX1-related.
Price, Horizon 106 genes: DKK 6,700

Broad coverage of parents-to-be of both Ashkenazi and Sephardic ancestry, with more than 100 conditions screened, with a combined likelihood of 1:2.

Who is the Horizon test suitable for?

The Horizon test is suitable for all couples who want to gain valuable insight into their likelihood of passing on genetic conditions to their future children. The test screens for cystic fibrosis, which is very common, spinal muscular atrophy or Duchenne / Becker muscular dystrophy – and many, many more.

It is possible to screen for a total of 274 genetic conditions.

Horizon can be performed at any time before or during pregnancy. Some people may want to know their carrier status before pregnancy to inform reproductive decisions.

You must be at least 18 to have the Horizon test performed.

The benefit of learning more through Horizon

If you and your partner are carriers, it is possible to establish whether your little one is affected through a placenta biopsy or amniocentesis.

If you are planning your pregnancy (and you know your carrier status), you can seek help to avoid having a baby who will be affected by any condition you or your partner might carry.

Horizon needs only be performed once in a lifetime.

Getting your test results

Your results are usually in after 7 -10 days. We will contact you by phone. We prefer to always call with the test results – both the good and the difficult ones.

In case you would like us to email you instead, please let us know at your appointment. We will send your report in an encrypted email.

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